ABSTRACT
Objectives@#To elucidate the prognostic impact of preoperative control of nutritional status (CONUT) scores on gastric cancer patients undergoing adjuvant chemotherapy after radical gastrectomy.@*Methods@#A retrospective analysis of 536 stage Ⅱ-Ⅲ gastric cancer patients undergoing adjuvant chemotherapy after radical resection from Jul 1998 to Dec 2014 was performed. Patients were divided into high (≥3) and low (≤2) CONUT groups with a CONUT score of 3 divided into critical values.@*Results@#The 5-year survival rate of the high CONUT group was significantly lower than that of the low CONUT group (37.3 % vs. 55.7%, P<0.001). Univariate analysis showed that the high CONUT group was associated with larger tumors, more lymph node metastasis, lower body mass index, higher prognostic nutritional index, and preoperative anemia (all P<0.05). Multivariate analysis showed that the CONUT score was an independent prognostic factor for patients with gastric cancer (HR: 1.564, 95% CI: 1.090-2.321, P=0.016). The 5-year survival rate of the high CONUT group was significantly lower than that of the low CONUT group (P<0.05).@*Conclusion@#The CONUT score is an indicator for predicting the prognosis of patients with stage Ⅱ-Ⅲ gastric cancer after adjuvant chemotherapy. The nutritional evaluation is helpful to develop a plan for preoperative nutritional intervention.
ABSTRACT
Objectives To elucidate the prognostic impact of preoperative control of nutritional status (CONUT) scores on gastric cancer patients undergoing adjuvant chemotherapy after radical gastrectomy.Methods A retrospective analysis of 536 stage Ⅱ-Ⅲ gastric cancer patients undergoing adjuvant chemotherapy after radical resection from Jul 1998 to Dec 2014 was performed.Patients were divided into high (≥ 3) and low (≤ 2) CONUT groups with a CONUT score of 3 divided into critical values.Results The 5-year survival rate of the high CONUT group was significantly lower than that of the low CONUT group (37.3 ％ vs.55.7％,P ＜0.001).Univariate analysis showed that the high CONUT group was associated with larger tumors,more lymph node metastasis,lower body mass index,higher prognostic nutritional index,and preoperative anemia (all P ＜ 0.05).Multivariate analysis showed that the CONUT score was an independent prognostic factor for patients with gastric cancer (HR:1.564,95％ CI:1.090-2.321,P =0.016).The 5-year survival rate of the high CONUT group was significantly lower than that of the low CONUT group (P ＜ 0.05).Conclusion The CONUT score is an indicator for predicting the prognosis of patients with stage Ⅱ-Ⅲ gastric cancer after adjuvant chemotherapy.The nutritional evaluation is helpful to develop a plan for preoperative nutritional intervention.